Brain-derived neurotrophic factor and suicidal behavior

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Commentary Brain-derived neurotrophic factor and suicidal behavior

Studies of the neurobiology of suicidal behavior have become an important and integral part of psychiatric research. Over the past several years, studies of the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidality have attracted significant interest of researchers. Multiple lines of evidence including studies of levels of BDNF in blood cells and plasma of suici...

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Brain-derived neurotrophic factor and suicidal behavior in patients with posttraumatic stress disorder.

Posttraumatic stress disorder (PTSD) is a severe illness affecting a substantial part of the population in both Western and developing countries. Many individuals suffering from PTSD display suicidal behavior. The association between PTSD and suicidal behavior has been observed both in clinical and in general population samples and is irrespective of the type of trauma that led to PTSD. The neu...

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Involvement of Mice Hippocampus Brain-derived Neurotrophic Factor in Diazinon-induced Depressive Behavior in Mice

Background: Diazinon (Dzn), an Organophosphorus (OP) pesticide, is extensively used in agriculture. Acetylcholinesterase inhibition is linked to OP toxicity, and there are major mental health concerns associated with the use of pesticides. The objective of this study was to assess the depressive behavior in an animal model following their exposure to Dzn and the effect on the Brain-Derived Neur...

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The role of brain-derived neurotrophic factor in the pathophysiology of suicidal behavior.

Suicidal behaviour is a major public health concern. It is known that the pathogenesis of suicidal behaviour involves altered neural plasticity, resulting in the aberrant stress response of the central nervous system to environmental factors. Indeed, altered brain structure and function was found in suicide victims. Neurotrophins are growth factors that are involved in the regulation of structu...

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Brain-derived neurotrophic factor:

Dekan Summary BDNF (brain-derived neurotrophic factor) plays an important role in neuronal survival, growth and maintenance of several neuronal systems, serves as neurotransmitter modulator and participates in plasticity important for learning and memory. BDNF is widely expressed in the CNS, beginning early in development and extending throughout life. In the mammalian brain, it is most abundan...

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ژورنال

عنوان ژورنال: QJM

سال: 2010

ISSN: 1460-2725,1460-2393

DOI: 10.1093/qjmed/hcq207